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Predictors of overall and recurrence-free survival after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma: Pooled analysis of individual patient data (IPD) from randomized controlled trials (RCTs).

Identifieur interne : 000569 ( Main/Exploration ); précédent : 000568; suivant : 000570

Predictors of overall and recurrence-free survival after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma: Pooled analysis of individual patient data (IPD) from randomized controlled trials (RCTs).

Auteurs : U. Ronellenfitsch [Allemagne] ; M. Schwarzbach [Allemagne] ; R. Hofheinz [Allemagne] ; P. Kienle [Allemagne] ; K. Nowak [Allemagne] ; M. Kieser [Allemagne] ; T E Slanger [Allemagne] ; B. Burmeister [Australie] ; D. Kelsen [États-Unis] ; D. Niedzwiecki [États-Unis] ; C. Schuhmacher [Allemagne] ; S. Urba [États-Unis] ; C. Van De Velde [Pays-Bas] ; T N Walsh [Irlande (pays)] ; M. Ychou [France] ; K. Jensen [Allemagne]

Source :

RBID : pubmed:28551325

Descripteurs français

English descriptors

Abstract

Neoadjuvant chemotherapy improves prognosis of patients with locally advanced gastroesophageal adenocarcinoma. The aim of this study was to identify predictors for postoperative survival following neoadjuvant therapy. These could be useful in deciding about postoperative continuation of chemotherapy.

DOI: 10.1016/j.ejso.2017.05.005
PubMed: 28551325


Affiliations:


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Le document en format XML

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<title xml:lang="en">Predictors of overall and recurrence-free survival after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma: Pooled analysis of individual patient data (IPD) from randomized controlled trials (RCTs).</title>
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<nlm:affiliation>The Alliance for Clinical Trials in Oncology (Alliance) Statistics and Data Center, Duke University Medical Center, Hock Plaza, 2424 Erwin Rd, Room 8040, Durham, NC 27705, USA. Electronic address: donna.niedzwiecki@duke.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
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<name sortKey="Urba, S" sort="Urba, S" uniqKey="Urba S" first="S" last="Urba">S. Urba</name>
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<nlm:affiliation>Division of Hematology/Oncology, University of Michigan Medical Center, 1500 E Medical Center Drive, C347, SPC 5848, Ann Arbor, MI 48109, USA. Electronic address: surba@med.umich.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology/Oncology, University of Michigan Medical Center, 1500 E Medical Center Drive, C347, SPC 5848, Ann Arbor, MI 48109</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van De Velde, C" sort="Van De Velde, C" uniqKey="Van De Velde C" first="C" last="Van De Velde">C. Van De Velde</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgery, Leiden University Medical Center, K6-R, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Electronic address: c.j.h.van_de_velde@lumc.nl.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgery, Leiden University Medical Center, K6-R, P.O. Box 9600, 2300 RC Leiden</wicri:regionArea>
<wicri:noRegion>2300 RC Leiden</wicri:noRegion>
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</author>
<author>
<name sortKey="Walsh, T N" sort="Walsh, T N" uniqKey="Walsh T" first="T N" last="Walsh">T N Walsh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgery, Connolly Hospital, Blanchardstown, Dublin 15, Ireland. Electronic address: proftnwalsh@gmail.com.</nlm:affiliation>
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<wicri:regionArea>Department of Surgery, Connolly Hospital, Blanchardstown, Dublin 15</wicri:regionArea>
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<author>
<name sortKey="Ychou, M" sort="Ychou, M" uniqKey="Ychou M" first="M" last="Ychou">M. Ychou</name>
<affiliation wicri:level="1">
<nlm:affiliation>Centre Régional de Lutte Contre le Cancer, Val d'Aurelle, Montpellier Cedex 05, France. Electronic address: marc.ychou@icm.unicancer.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Régional de Lutte Contre le Cancer, Val d'Aurelle, Montpellier Cedex 05</wicri:regionArea>
<wicri:noRegion>Montpellier Cedex 05</wicri:noRegion>
<wicri:noRegion>Montpellier Cedex 05</wicri:noRegion>
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<author>
<name sortKey="Jensen, K" sort="Jensen, K" uniqKey="Jensen K" first="K" last="Jensen">K. Jensen</name>
<affiliation wicri:level="3">
<nlm:affiliation>Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130, 69120 Heidelberg, Germany. Electronic address: jensen@imbi.uni-heidelberg.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</author>
</analytic>
<series>
<title level="j">European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology</title>
<idno type="eISSN">1532-2157</idno>
<imprint>
<date when="2017" type="published">2017</date>
</imprint>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adenocarcinoma (drug therapy)</term>
<term>Adenocarcinoma (surgery)</term>
<term>Chemotherapy, Adjuvant</term>
<term>Esophageal Neoplasms (drug therapy)</term>
<term>Esophageal Neoplasms (surgery)</term>
<term>Humans</term>
<term>Neoadjuvant Therapy</term>
<term>Prognosis</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Stomach Neoplasms (drug therapy)</term>
<term>Stomach Neoplasms (surgery)</term>
<term>Survival Rate</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adénocarcinome ()</term>
<term>Adénocarcinome (traitement médicamenteux)</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Pronostic</term>
<term>Résultat thérapeutique</term>
<term>Taux de survie</term>
<term>Traitement médicamenteux adjuvant</term>
<term>Traitement néoadjuvant</term>
<term>Tumeurs de l'estomac ()</term>
<term>Tumeurs de l'estomac (traitement médicamenteux)</term>
<term>Tumeurs de l'oesophage ()</term>
<term>Tumeurs de l'oesophage (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Adenocarcinoma</term>
<term>Esophageal Neoplasms</term>
<term>Stomach Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Adenocarcinoma</term>
<term>Esophageal Neoplasms</term>
<term>Stomach Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Adénocarcinome</term>
<term>Tumeurs de l'estomac</term>
<term>Tumeurs de l'oesophage</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Chemotherapy, Adjuvant</term>
<term>Humans</term>
<term>Neoadjuvant Therapy</term>
<term>Prognosis</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Survival Rate</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adénocarcinome</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Pronostic</term>
<term>Résultat thérapeutique</term>
<term>Taux de survie</term>
<term>Traitement médicamenteux adjuvant</term>
<term>Traitement néoadjuvant</term>
<term>Tumeurs de l'estomac</term>
<term>Tumeurs de l'oesophage</term>
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<front>
<div type="abstract" xml:lang="en">Neoadjuvant chemotherapy improves prognosis of patients with locally advanced gastroesophageal adenocarcinoma. The aim of this study was to identify predictors for postoperative survival following neoadjuvant therapy. These could be useful in deciding about postoperative continuation of chemotherapy.</div>
</front>
</TEI>
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<name sortKey="Kienle, P" sort="Kienle, P" uniqKey="Kienle P" first="P" last="Kienle">P. Kienle</name>
<name sortKey="Kieser, M" sort="Kieser, M" uniqKey="Kieser M" first="M" last="Kieser">M. Kieser</name>
<name sortKey="Nowak, K" sort="Nowak, K" uniqKey="Nowak K" first="K" last="Nowak">K. Nowak</name>
<name sortKey="Schuhmacher, C" sort="Schuhmacher, C" uniqKey="Schuhmacher C" first="C" last="Schuhmacher">C. Schuhmacher</name>
<name sortKey="Schwarzbach, M" sort="Schwarzbach, M" uniqKey="Schwarzbach M" first="M" last="Schwarzbach">M. Schwarzbach</name>
<name sortKey="Slanger, T E" sort="Slanger, T E" uniqKey="Slanger T" first="T E" last="Slanger">T E Slanger</name>
</country>
<country name="Australie">
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<name sortKey="Burmeister, B" sort="Burmeister, B" uniqKey="Burmeister B" first="B" last="Burmeister">B. Burmeister</name>
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<region name="État de New York">
<name sortKey="Kelsen, D" sort="Kelsen, D" uniqKey="Kelsen D" first="D" last="Kelsen">D. Kelsen</name>
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<name sortKey="Van De Velde, C" sort="Van De Velde, C" uniqKey="Van De Velde C" first="C" last="Van De Velde">C. Van De Velde</name>
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<name sortKey="Walsh, T N" sort="Walsh, T N" uniqKey="Walsh T" first="T N" last="Walsh">T N Walsh</name>
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